"Addicted to one-night stands or dependent on one another?"
Maggie is an alluring free spirit who won't let anyone – or anything – tie her down. But she meets her match in Jamie, whose relentless and nearly infallible charm serves him well with the ladies and the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
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Jake GyllenhaalJamie Randall
Anne HathawayMaggie Murdock
Oliver PlattBruce Winston
Hank AzariaDr. Stan Knight
Josh GadJosh Randall
Gabriel MachtTrey Hannigan
Judy GreerCindy
Jill ClayburghNancy Randall
George SegalDr. James Randall
Kate Jennings GrantGina
Katheryn Winnick"Lisa"
Kimberly ScottGail
Peter FriedmanCalifornia Man
Nikki DeLoachChristy
Natalie GoldDr. Helen Randall
Megan FergusonFarrah
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